Microbial Conversion Products of Leptomycin B
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چکیده
منابع مشابه
Microbial conversion products of leptomycin B.
Leptomycin B (LMB), a secondary metabolite produced by Streptomyces sp. strain ATS 1287, with known antifungal and antitumor effects, inhibits the nucleo-cytoplasmic translocation of the human immunodeficiency virus type 1 regulatory protein Rev and exhibits significant antiproliferative activity. Since LMB itself turned out to be distinctly cytotoxic, a bioconversion screening with a selected ...
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Streptomyces galilaeus OBB-111 and its blocked mutant were found to convert aclacinomycin B and related anthracycline glycosides of the B type to the corresponding A-type glycosides. Only the cell fraction of cultures of S. galilaeus OBB-111 was capable of catalyzing the reaction. The activity was associated with growth but disappeared before the start of rapid production of aclacinomycins A an...
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Four selected azo dyes (acid orange 6, acid orange 7, methyl orange and methyl red) were completely decolourised in the presence of anaerobic granular sludge, while only methyl red was degraded in aerobic conditions using a conventional activated sludge. Additional experiments with culture broth devoid of cells showed that anaerobic decolourisation of azo dyes was performed by extracellular red...
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Bacteria, actinomycetes, yeasts, and fungi were screened for their ability to modify the structure of ansamitocins, a group of antitumor ansamycin antibiotics. Many strains, mostly actinomycetes, were found to convert ansamitocin P-3 to one or more products. These products, compounds A, B, C, and D, were prepared using Bacillus megaterium IFO 12108, Streptomyces coelicolor IFO 3807, Streptomyce...
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ژورنال
عنوان ژورنال: Applied and Environmental Microbiology
سال: 1998
ISSN: 0099-2240,1098-5336
DOI: 10.1128/aem.64.2.714-720.1998